The film had nine nominations, including the best film category, and it won in the best director, best cinematographer (Benoît Debie), best production design (Michel Barthélémy) and best sound (Brigitte Taillandier, Valérie de Loof, Cyril Holts) categories.  

The Polish/British/French coproduction Cold War directed by Pawel Pawlikowski and produced by Opus Film in coproduction with Apocalypso Pictures, was nominated in the foreign-language category, where the winner was Hirokazu Kore-eda's Palme d'Or winner Shoplifters.

The Sisters Brothers is a coproduction between Why Not Productions (France), Les Films du Fleuve (Belgium), Mobra Films (Romania) and Menakoz Films (Spain). The Romanian coproducers are Cristian Mungiu and Tudor Reu.

The Sisters Brothers started its international career at the 2018 Venice Film Festival, where Jacques Audiard was awarded best director.